Respiratory system

Lung development: Phases

"Every Premature Child Takes Air"

  • Embryonic period
  • Pseudoglandular period
  • Canalicular period
  • Terminal sac period
  • Alveolar period

Oxygen-haemoglobin dissociation curve: Effect of shifts


"L-L-L" & "R-R"

  • Left shift: causes Loading of O2 into Hb ( Eg. At the  Lungs). Oxygen-haemoglobin dissociation curve  
  • Right shift: causes Release of O2 from Hb.



Hemoglobin and Myoglobin-Binding sites,strengths

  • "ABC" of glycosylated Hb (Hb1c):Glucose binds to Amino terminal of Beta Chain.
  • "HbF binds Forcefully": HbF binds oxygen more forcefully than HbA, so Oxy-Hb dissociation curve shifts to left.
  • Stored blood is SOS: Stored blood Hb binds to Oxygen Strongly because of decrease in 2,3 BPG.
  • 2,3 BPG binding site is BBC: BPG binds to

Oxygen-haemoglobin dissociation curve: Causes of shift to right

CADET, face Right!

  • CO2  Oxygen-haemoglobin dissociation curve
  • Acid
  • 2,3-DPG(aka 2,3-BPG)
  • Exercise
  • Temperature
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