Autoimmune rheumatic disorder, pathogenesis, precipitating factors, pathology, clinical features- Constitutional symptoms, musculoskelatal and cutaneous- DLE, butterfly rash, renal, neurological, CVS- verrucous endocarditis, livedo reticularis, raynaud phenomenon, pulmonary, hematological, gastrointestinal, ocular. Diagnostic criteria, investigations, autontibodies, management in general, major drugs, prognosis and outcome, death, drug induced lupus.