Drugs following zero order pharmacokinetics
' Peas & WHEATS '
- Phenytoin, Phenylbutazone
- Warfarin
- Heparin
- Ethanol
- Aspirin
- Theophylline, Tolbutamide
- Salicylates
A Pea would look like a zero and denotes the order.
Pea also stands for ' Pee' ing out a constant amount as in zero order kinetics constant amount of the drug is eliminated per unit time. Rate of elimination is constant and does not depend on or vary with the drug intake or plasma concentration of the drug.
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Did you know?
 Very few drugs follow pure zero order pharmacokinetics (non linear pharmacokinetics), e.g.alcohol. |
| Any drug at high concentration may show zero order kinetics, when its metabolic or elimintaion pathway is saturated. |
Comments
Submitted by varunbhb on Fri, 09/03/2012 - 01:41.
phenytoin can have both zero order and first order kinetics . at low conc it has first order kinetics and at high conc it has zero order kinetics
in zero order kinetics -- same amount of drug is metabolised
in first order kiinetics-- same proportion of drug is metabolized with increasng of concentration
Submitted by lifehugger on Tue, 25/09/2012 - 13:33.
Thanks Varun.
I was not knowing the concept of Pea before which is related to the drugs. So, it was nice to know about it.
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