Atropinization: Signs and symptoms

" 8D' s "

  • Delirium (disorientation)
  • Drowsiness
  • Dilated pupils (The mydriasis along with cyclopegia causes blurring of vision)
  • Dryness of mouth
  • Dysphagia
  • Drunken gait
  • Dry, hot skin
  • Death due to respiratory failure

 Atropine is the prototype drug of the anticholinergic class which act by blocking muscarinic or nicotinic (neuromuscular blockers and ganglion blockers) receptors. This mnemonic can aslo be used to remember the 'side effects of anticholinergics' .

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imageAtropine is a natural alkaloid obtained from Atropa belladona.
imageAtropine is highly selective for muscarinic receptors. Some of its synthetic forms also have additional nicotinic blocking property.
imageAtropine is contra-indicated in children due to the high risk of hyperthermia because of decreased sweating in them.

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