SLE: Signs and symptoms, diagnostic criteria
According to the guidelines of American College of Rheumatology a person can be diagnosed to have SLE if any 4 out of the11 symptoms are present simultaneously or serially on two seperate occasions.
' SOAP BRAIN MD'
- Serositis (pleuritis, pericarditis)
- Oral ulcers
- Arthritis (2 or more peripheral joints)
- Blood changes (anemia, leukopenia, thrombocytopenia-ie., a fall in all parameters )
- Renal involvement (persistent proteinuria>0.5g/day or cellular casts-due to immune complex deposition in kidney)
- ANA + (detected by immunofluorescence)
- Immunologic changes (Antibodies against double-stranded DNA,Sm antigen)
- Neurologic (seizures,psychosis)
- Malar rash
- Discoid rash.
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Did you know?
Systemic Lupus Erythematosus(SLE ) is a multisystem disease of autoimmune origin.It is characterised by formation of vast array of autoantibodies,particularly antinuclear antibodies(ANAs).