SLE: Signs and symptoms, diagnostic criteria

According to the guidelines of American College of Rheumatology a person can be diagnosed to have SLE if any 4 out of the11 symptoms are present simultaneously or serially on two seperate occasions.

' SOAP BRAIN MD'

  • Serositis  (pleuritis, pericarditis)
  • Oral ulcers
  • Arthritis  (2 or more peripheral joints)
  • Photosensitivity
  • Blood changes  (anemia, leukopenia, thrombocytopenia-ie., a fall in all parameters )
  • Renal involvement (persistent proteinuria>0.5g/day or cellular casts-due to immune complex deposition in kidney)
  • ANA +   (detected by immunofluorescence)
  • Immunologic changes (Antibodies against double-stranded DNA,Sm antigen)
  • Neurologic  (seizures,psychosis)
  • Malar rash
  • Discoid rash.
4

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Systemic Lupus Erythematosus(SLE ) is a multisystem disease of autoimmune origin.It is characterised by formation of vast array of autoantibodies,particularly antinuclear antibodies(ANAs).


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