Possible causes of Pyrexia of Unknown origin (PUO)


  • Infections:        
  •  Malignancy
  • Automimmune Diseases
  • Granulomas (Sarcoidosis, Crohn's disease)
  • Iatrogenic (Drug fever, Thrombophlebitis)
  • Nurses, Doctors and all paramedical staff: factitious fever
  • Etc


Infections can be any. Some of the common presentations are:

  • Bacterial: TB, Typhoid, Bacillary endocarditis and septicemia, Abscess (subphrenic, intrahepatic etc)                    
  • Viral: Hep B, Protozoal:malaria, amoebiasis, spirochaetes



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