Klinefelter's syndrome (KS)

Submitted by Nishanth_koda on Wed, 06/07/2011 - 21:47
in

"Mr. K-LINE FELT  Some  Bar Guys"

  • Male phenotype
  • Karyotype, most common is 47,XXY
  • Long stature
  • Infertility, Incidence: 1 in 1000 men
  • Nondisjunction of sex chromosomes
  • Eunuchoid body proportions
  • FSH elevated, scanty Facial & axillary hair
  • Estradiol/testosterone ratio elevation
  • LH elevated, Leukemias (increased risk for AML) & breast tumors, Learning disability
  • Testosterone reduced, small (hyalinized) Testes & penis
  • Secondary sexual characters absent
  • Barr body +ve
  • Gynecomastia

 

 "FEL" of FELT deals with hormonal status in KS. Normally, LH induces testosterone synthesis which by feedback inhibition reduces LH & FSH secretion from anterior pituitary. In KS, as testoterone level is low, there is no feedback inhibition and level of LH & FSH rises. Also low testosterone leads to failure of male secondary sexual characters development (small testis & penis) and the increase in estradiol (high estradiol/testosterone ratio) causes gynecomastia.

 

 

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Comments

Submitted by Chaas (not verified) on Fri, 19/08/2011 - 19:36.

And I was just wondienrg about that too!

Submitted by Cordelia (not verified) on Thu, 18/08/2011 - 06:41.

That addrseses several of my concerns actually.

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