Scleroderma: Clinical Features
" SCLERODERMA "
- CREST syndrome, Capillaroscopy as diagnostic tool
- Lung involvement: pulmonary fibrosis, pulmonary HTN, aspiration pneumonia, recurrent chest infection, bronchoalveolar ca, pneumothorax
- Liver disease and primary biliary cirrhosis
- Exposure to environmental toxins like organic solvents, hydrocarbons and silica as aetiology
- Renal crisis, HTN, Renal failure
- Oral vasodilators as treatment of choice for Raynaud's disease
- Digital ischaemia leading to autoamputation, Dry eyes, D-pencillamine as Rx
- Doppler Echo as diagnostic tool for pul.HTN
- Endoscopy to assess GI involvement
- Resorption of phalanges due to bone ischaemia
- Microstomia, Malabsorpion syndromes, Myocarditis, Myocardial fibrosis
- Anti scl 70, Anti-centromere antibodies; ACE inhibitors as useful therapy
This work is licensed under a Creative Commons Attribution-Share Alike 3.0 license.
Did you know?
|ACE inhibitors may dramatically improve scleroderma renal crisis|
|All patients should be followed carefully for the change in P2 as an evidence of decompensation with pulmonary hypertension|
|CREST/ CRST syndrome: Calcinosis, Raynaud's (WBC: White-Blue-Crimson color changes), Esophageal dysmotility, Sclerodactyly & Telangiectasia|