Acromegaly: Clinical features
Acromegaly is due to hypersecretion of growth hormone from a macroadenoma. Acromegaly develops insidiously and recognising a classic case of acromegaly is not difficult.
You can memorise the features by just remembering the mnemonic,
- Acral enlargement - leading to usage of larger shoes, gloves, rings or even dentures
- Carpal Tunnel Syndrome, Coarse facial features, Cardiovascular disease, Cardiomyopathy
- Reduced life span due to increased CVD (and colorectal cancers)
- OSA, Osteopaenia, Osteoporosis
- Entrapment neuropathy, soft tissue Enlargement
- Abnormal GTT, bitemporal hemiAnopia
- Loss of libido, Lipid abnormality
- IGF incresed
- Colorectal cancer risk is increased
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Did you know?
|Some of the terms like 'spade hands' used to describe acromegaly in many text books are insulting and of little practical use.|
|Mortality is increased two to three fold in acromegaly due to cardiovascular and cardiorespiratory diseases and malignancies.|
|Diagnosis is confirmed by GTT and elevated IGF-1.|