"A+.B.C.D.E"
- Aminoglycosides* (Profound and irreverible hair cell loss)
- Barbiturates
- Cytotoxic drugs-Nitrogen mustard & cisplatin affect Organ of corti (irreversible)
- Diuretics-Ethacrynic acid, frusemide cause Ionic changes (reversible)
- Etc.
*Kanamycin, neomycin & dihydrostreptomycin are cochleotoxic. Streptomycin, gentamicin & tobramycin are vestibulotoxic.
Gentamicin overdose can cause bouncing vision, or oscillopsia.