General pharmacology

Drugs undergoing complete First pass metabolism

Drugs undergoing complete first pass metabolism when taken orally

'F I L T Hy'

  • First pass metabolism
  • Isoprenaline
  • Lignocaine
  • Testosterone
  • Hydrocortisone

4.5

Enzyme inhibitors

"Vit. K Cannot Cause Enzyme Inhibition"

  • Valproate
  • Ketaconazole
  • Cimetidine
  • Ciprofloxacin
  • Erythromycin
  • INH

 

4

Ototoxicity: Causative agents

"A+.B.C.D.E"

  • Aminoglycosides* (Profound and irreverible hair cell loss)
  • Barbiturates
  • Cytotoxic drugs-Nitrogen mustard & cisplatin affect Organ of corti (irreversible)
  • Diuretics-Ethacrynic acid, frusemide cause Ionic changes (reversible)
  • Etc.

 

*Kanamycin, neomycin & dihydrostreptomycin are cochleotoxic. Streptomycin, gentamicin & tobramycin are vestibulotoxic.

5

Enzyme inducers

 ' P RAGA

  • Phenylbutazone
  • Anticonvulsants
  • Rifampicin
  • Griseofulvin
  • Alcohol
3
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